Organic–Inorganic Hybrid Nanoparticles Synthesized with <i>Hypericum perforatum</i> Extract: Potential Agents for Photodynamic Therapy at Ultra-low Power Light

A progressive way in photodynamic therapy is to design photosensitive agents that may operate at lower optical power. Hybrid organic–inorganic silver-, iron-, and silver&iron-contained nanoparticles (NPs) were synthesized using H. perforatum extract explored as photosensitizers for anticancer antimicrobial therapies ultra-low power light (2.30 mW/cm2). silver- NPs revealed the most promising results therapy: a concentration of 25 μg/mL, difference between viability non-radiated irradiated HeLa cells was up 71%. Importantly, cancer are more assailable hybrid NP activity than normal fibroblast MSU-1.1 cell line, which observed both “dark” cytotoxicity DCFH-DA assays. Oxidative stress induced by iron- higher (≥1.7 times) cells. For therapy, (at μg/mL) found be being bacteriostatic against E. coli S. aureus condition bactericidal after irradiation. Antimicrobial properties result synergy activities silver. The highest efficiency bacteria achieved concentrations conditions silver apart less or not active. Furthermore, combine with ability enhance magnetic resonance imaging (MRI) contrast. This combination makes these materials biomedical application near-surface inflammatory disorders, possibility their visualization MRI.